N-Acetyl Selank Amidate Nasal Spray | A-Z Guide

Researchers conducting studies into nootropics may have heard about N-Acetyl Selank Amidate nasal spray.

This peptide is a modified version of the potent anxiolytic and nootropic peptide Selank. The modifications are suggested to improve the pharmacokinetics of the peptide, while at the same time it is expected to have the following benefits:

• Nootropic effects
• Anxiolytic effects
• Stress-reduction
• Anti-inflammatory effects

This article will explore the most notable insights on N-Acetyl Selank Amidate nasal spray for cognitive enhancement research, covering everything from dosage and safety to administration and storage.

Dive deeper to uncover the peptide's research potential and find out where to source the highest-quality N-Acetyl Selank Amidate nasal spray.

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What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is an acetylated and amidated version of the nootropic peptide Selank. The latter was developed in Russia and currently available in Russian pharmacies for therapy in anxiety [1].

Both peptides have the same amino acid chain composed of the tetrapeptide tuftsin (threonine – lysine – proline – arginine) and a Pro-Gly-Pro fragment at the C-terminus.

The additional modifications of N-Acetyl Selank Amidate are thought to protect the N- and C-terminal groups from breakdown and increase the stability of the peptide [2, 3].

As a result, N-Acetyl Selank Amidate is a heptapeptide that can pass the blood-brain barrier (BBB) and possesses enhanced stability following intranasal administration [4].

Unlike Selank, which has been approved for generalized anxiety disorder (GAD) therapy since 2009 and is under active investigation for its potential nootropic, neuroprotective, and immunomodulatory properties, N-Acetyl Selank Amidate is yet to be included in research [1, 5, 6, 7].

As a modified peptide, N-Acetyl Selank Amidate is thought to possess the same benefits combined with improved pharmacokinetics. The peptide is available as a research chemical for educational and experimental purposes.

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How N-Acetyl Selank Amidate Works

Currently, there is no research delving into the potential mechanisms of N-Acetyl Selank Amidate action. Yet the peptide is considered to produce similar effects to Selank, while boasting improved stability. Thus, it may be worth considering Selank's mechanisms as a reference.

Selank exerts its effects by interacting with a wide range of molecules and mediators in the central nervous system (CNS), including:

• Selank acts as a positive modulator for gamma amino butyric acid (GABA), an inhibitory neurotransmitter that plays a crucial role in reducing neuronal excitability. By enhancing GABA's effects, Selank can effectively alleviate anxiety symptoms [4].
• Selank is known to stimulate serotonin metabolism, a key process in mood regulation. Enhanced serotonin levels are associated with improved emotional well-being and reduced symptoms of depression [8].
• Research indicates that Selank elevates enkephalin levels by inhibiting the enzymes responsible for their degradation. Enkephalins are physiological ligands for opioid receptors, suggesting that Selank may benefit mood and stress management [9, 10, 11].
• Selank may increase the Brain-derived neurotrophic factor (BDNF) expression in the brain's hippocampal region. BDNF is essential for neuronal survival and synaptic plasticity, and its increased expression could contribute to enhanced resilience against stress [12].
• Selank may interact synergistically with neurotransmitters such as dopamine and norepinephrine. This interaction could amplify Selank's anxiolytic and nootropic effects, making it a multifaceted agent for mental health support [13].

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Benefits of N-Acetyl Selank Amidate

Given the lack of both preclinical and clinical research on intranasal N-Acetyl Selank Amidate, it's important to rely on existing data for intranasal Selank to understand its potential benefits.

We anticipate that N-Acetyl Selank Amidate may offer similar, if not enhanced, effects compared to its parent compound, Selank. Below, we've detailed the key advantages of intranasal Selank, as supported by clinical evidence.

Anxiolytic and Anti-Stress Effects

As mentioned, intranasal Selank is officially approved in Russia as a therapy for GAD. Below, we have outlined some of the most notable studies on Selank, which can be used as a reference for N-Acetyl Selank Amidate nasal spray's potential effects:

• In a clinical study involving 60 adults with anxiety disorders, a two-week regimen of intranasal Selank therapy yielded significant anxiolytic benefits. Notably, the anxiety-reducing effects of Selank were sustained for an entire week following the conclusion of the 14-day treatment. Additionally, the study observed that Selank exhibited mild nootropic properties, enhancing cognitive function [5].
• Another trial in 62 individuals diagnosed with Generalized Anxiety Disorder (GAD) compared intranasal Selank vs. a highly effective anxiolytic medication called medazepam. The trial revealed that intranasal Selank, given in doses of up to 2700mcg/daily, is just as potent for reducing anxiety symptoms as the medication. The peptide also improved the tau (1/2) leu-enkephalin levels, which is a physiological mediator for the opioid receptors, and it was reduced in subjects with GAD [11].

Memory Enhancement and Nootropic Effects

N-Acetyl Selank Amidate nasal spray is expected to possess similar nootropic potential as intranasal Selank's memory-enhancing properties, described in the following studies:

• A clinical trial in 70 subjects with anxiety disorders investigated the effects of combined therapy with intranasal Selank and the oral anxiolytic drug phenazepam. Adding Selank to the therapy led to a significantly lower risk of phenazepam's side effects, such as dizziness, drowsiness, and lack of concentration. The peptide exerted nootropic effects, which helped ameliorate memory loss, asthenia, and attention deficits among the treated participants [14].
• Selank has been reported to increase memory trace stability in test animals for up to 30 days following administration. These effects were suggested to be potentially related to Selank's serotonin-boosting properties [6].
• In another animal trial, Selank was administered to rats with impaired learning abilities, and its potential was compared to the nootropic medication piracetam. A single dose of the peptide led to significant improvement in the learning abilities of the animals, and the effects progressed during the first three days of repeated administration, reaching greater effectiveness than piracetam [15].

Neuroprotection and Anti-inflammatory effects

Clinical and preclinical studies indicate that intranasal Selank possesses both anti-inflammatory and neuroprotective capabilities, particularly to subjects under stressful conditions. These findings offer valuable insights into the therapeutic potential of N-Acetyl Selank Amidate nasal spray:

• In a clinical study, a two-week course of intranasal Selank was shown to downregulate IL-6 gene expression in the blood of depressed patients. Additionally, the drug optimized the Th1/Th2 cytokine balance in individuals with Generalized Anxiety Disorder (GAD), suggesting its efficacy in mitigating CNS inflammation in anxiety conditions [7].
• Animal research corroborates Selank's anti-inflammatory action within the CNS. In a specific trial, animals subjected to social stress exhibited elevated levels of pro-inflammatory cytokines like IL-1β, IL-6, and TGF-β1. Selank treatment normalized these levels and also replenished the anti-inflammatory cytokine IL-4, which typically diminishes under stress [16].
• Preclinical studies further hint at Selank's neuroprotective qualities. One experiment demonstrated that Selank protected the CNS of test animals against the neurotoxic effects of chronic alcohol consumption in rats. The peptide prevented memory and attention deficits, an outcome attributed to its modulation of BDNF levels [17].

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Side Effects and Safety

While there's a lack of specific research on the safety and side effects of intranasal N-Acetyl Selank Amidate, existing studies on intranasal Selank offer some insights.

Approved in Russia for treating Generalized Anxiety Disorder (GAD), Selank appears safe and effective when administered at a maximum dosage of 2700mcg per day for 14-21 days, and the available trials do not report any side effects [11, 13].

Moreover, Selank has been reported to counteract the adverse effects commonly associated with other anxiolytics like benzodiazepines.

The method of intranasal administration also offers great safety, although potential minor side effects may occur, such as:

• Nasal dryness
• Throat irritation
• Hypersensitivity
• Infections

N-Acetyl Selank Amidate may boost BDNF expression, and elevated BDNF levels have been linked to hair loss. Yet, there is no research linking hair loss with the use of N-Acetyl Selank Amidate or related peptides [18].

Due to the potential effect of the peptide on GABA signaling, some researchers have also suggested a potential risk of GABA desensitization after long term use, Once again, no studies confirm this risk [19].

Still, researchers must recognize that the long-term safety of both Selank and N-Acetyl Selank Amidate remains largely unexplored beyond 14 days and cycle it off after two weeks of use.

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N-Acetyl Selank Amidate Nasal Spray Dosage

While there's no official dosing for N-Acetyl Selank Amidate due to limited research, guidelines for intranasal Selank can serve as a reference.

For example, Selank is available for GAD therapy as 0.15% nasal drops. The standard regimen involves two drops (75mcg per drop) three times a day for up to 14 days, totaling 450mcg/daily. A 1-3 weeks break is advised before resuming for another 14-day cycle [20].

Clinical trials have also tested Selank at doses up to 900mcg, administered three times a day for 21 days. Given that most N-Acetyl Selank Amidate sprays contain 0.3% concentration and deliver 300mcg per pump, trials could start with 2-3 pumps daily [13].

Researchers might follow Selank guidelines for cycle length up to 2 weeks, followed by a 1-3 week washout period. This cycling aims to minimize potential GABA-receptor desensitization, although no data confirm this risk for either Selank or its N-Acetyl variant [13, 20].

Here is a sample dosing protocol for N-Acetyl Selank Amidate that researchers may consider using as a reference:

• Daily Dosage: A total dose of 600-900mcg/daily, administered via one pump (300mcg) 2-3 times daily. Do not exceed 9 pumps a day.
• Frequency: Administer 2-3 times daily.
• Study Duration: Up to 14 days, followed by a minimum one-week break. A second two-week course may follow if needed.
• Monitoring: Closely watch for adverse reactions through EEG and clinical assessments. Discontinue administering if subjects develop any side effects.

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N-Acetyl Selank Amidate Nasal Spray Administration

Here is a simple step-by-step guide on administering N-Acetyl Selank Amidate nasal spray in research settings:

• Preparation: Ensure that the peptide is a homogenous solution, and gently roll the spray bottle between the hands. Avoid shaking to prevent denaturation.
• Subject readiness: Instruct each participant to clear his/hertheir nasal passages. Then, identify which nostril is more open to ensure optimal absorption of the spray.
• Disinfection: Thoroughly disinfect the hands. Additionally, sterilize the nozzle of the N-Acetyl Selank Amidate spray using an alcohol swab to ensure a hygienic application.
• Application: Utilizing the non-dominant hand, gently close off one of the participant's nostrils. Grasp the spray bottle firmly with the dominant hand. Slightly tilt the participant's head back for better access. Insert the nozzle deep into the open nostril and administer a single spray while guiding the participant to inhale gently.
• Timing: Allow a pause of 30-60 seconds between each spray to prevent mucosal oversaturation, ensuring maximum absorption and effectiveness.
• Repeating the administration: If additional doses are required, repeat the steps as needed.

After each use, remember to wipe the nozzle clean with an alcohol swab. And return the peptide to cold storage. The peptide should be refrigerated at all times, at temperatures from 36 to 46 degrees F.

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Where to Buy N-Acetyl Selank Amidate Nasal Spray?

Navigating the plethora of online vendors for research peptides like N-Acetyl Selank Amidate nasal spray can be challenging. Many vendors offer subpar products which can compromise research.

After a thorough evaluation, we have identified and strongly recommend a vendors that stands out with the quality of their intranasal peptides…

Limitless Life Nootropics

Here's a short list on why we endorse them:

• Guaranteed Purity: Limitless Life Nootropics ensures high-quality peptides verified through independent third-party lab testing. A comprehensive Certificate of Analysis is provided for customer assurance.
• Third-party Verification: The company goes the extra mile by sourcing itstheir products from accredited U.S. facilities and submitting all batches to third-party testing, further solidifying their commitment to quality.
• Cost-Effective and Flexible Payments: While specific pricing details vary, Limitless Life Nootropics accepts multiple payment options, including Revolut, CashApp, Zelle, and cryptocurrencies. Cryptocurrency users also benefit from discounts.
• Expedited Customer Service: Limitless Life Nootropics excels in customer service as it is easy to reach by phone or mail and promptly addresses any shipping discrepancies or other issues.

For these reasons, we endorse Limitless Life Nootropics as an exceptional supplier for intranasal N-Acetyl Selank Amidate.

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N-Acetyl Selank Amidate Nasal Spray | Verdict

N-Acetyl Selank Amidate is a research peptide that has the same amino acid sequence as Selank but also possesses a couple of modifications that improve its stability and pharmacokinetics.

Thus, the intranasal delivery N-Acetyl Selank Amidate is expected to have similar benefits to the parent peptide, including cognitive enhancement, stress reduction, anti-anxiety effects, and more.

For researchers interested in incorporating N-Acetyl Selank Amidate nasal spray into study, we highly recommend sourcing the peptide from a trusted vendor such as Limitless Life Nootropics.

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