N-Acetyl Selank Amidate Dosage Calculator and Chart

Scientists interested in nootropic research may be wondering about the appropriate N-Acetyl Selank Amidate dosage to apply in their experiments.

N-Acetyl Selank Amidate is a research peptide similar to Selank, with a couple of modifications to increase its stability. The peptide has been linked to the following benefits:

• Cognitive enhancement
• Anxiety reduction
• Improved resistance to stress

This article will summarize the latest information related to N-Acetyl Selank Amidate dosage for anti-stress and nootropic research.

Keep reading to discover details about the peptide’s research potential, safety, and side effects. Plus, we’ll also reveal our most trusted online vendors of research-grade N-Acetyl Selank Amidate.

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N-Acetyl Selank Amidate Dosage Chart | Quick Breakdown

Timeframe	Intranasal N-Acetyl Selank Amidate Dosage for Research	Injectable N-Acetyl Selank Amidate Dosage for Research
Weeks 1-2	1 pump (300mcg) x2-3 times daily (total of 600-900mcg/daily)	150-300mcg/daily
Week 3	Washout	Washout
Week 4-5	1 pump (300mcg) x2-3 times daily (total of 600-900mcg/daily)	150-300mcg/daily

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What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is a modified version of the potent nootropic and anxiolytic peptide Selank.

Selank was initially synthesized in the 1990s at Russia's Institute of Molecular Genetics and received approval for treating generalized anxiety disorder (GAD) in Russia and Ukraine in 2009 [1, 2, 3].

Like Selank, N-Acetyl Selank Amidate is a synthetic heptapeptide that incorporates the sequence of the immunomodulatory peptide tuftsin at the N-terminus and a Pro-Gly-Pro fragment at the C-terminus.

This structure allows the peptide to pass through the blood-brain barrier (BBB) and reach the central nervous system (CNS) following intranasal administration or subcutaneous injection [4, 5].

In addition, N-Acetyl Selank Amidate also features an acetyl group at the N-terminus and an amide group at the C-terminus to enhance its stability by safeguarding the terminal groups from degradation [6, 7].

While research on the specific effects of N-Acetyl Selank Amidate is scant, it's thought to share Selank's properties, given that its modifications aim at increasing the peptide’s stability rather than altering its function. Thus, it's reasonable to speculate that it works similarly to Selank.

Selank is known to interact with various neurotrophic factors and neurotransmitters in the CNS.

Here is a summary of its mechanisms:

• Selank is a positive modulator of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces neuronal excitability and alleviates anxiety [4].
• Selank boosts serotonin metabolism, which positively affects mood regulation [8].
• Selank has been shown to elevate enkephalin levels by blocking the enzymes that degrade them. Enkephalins are the physiological ligands for the opioid receptors, potentially aiding in mood and stress management [9, 10, 11].
• Selank may also increase brain-derived neurotrophic factor (BDNF) expression in the hippocampal area. This neurotrophic factor contributes to neuronal survival and synaptic plasticity, which may help increase resistance to stress [12].
• Selank may interact with dopamine and norepinephrine, which would further potentiate its anxiolytic and nootropic effects [13].

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Benefits of N-Acetyl Selank Amidate

In light of the limited clinical and preclinical information available on N-Acetyl Selank Amidate, we've detailed the primary advantages of Selank. N-Acetyl Selank Amidate is expected to offer similar benefits, potentially enhanced by the peptide’s increased stability.

Nootropic Effects

Numerous trials indicate that Selank could exhibit cognition-enhancing properties, particularly in individuals suffering from anxiety disorders. Here are the most notable study findings:

• One study of 70 patients with anxiety disorders compared the efficacy and tolerability of the anxiolytic phenazepam alone versus a combination of selank and phenazepam. Selank significantly enhanced phenazepam’s effectiveness while reducing its common cognitive side effects, such as attention and memory impairment, asthenia, sedation, and emotional indifference [14].
• A murine study reported that a single injection of Selank (300 microg/kg) activated serotonin metabolism in the hypothalamus and caudal brainstem for 30 minutes to 2 hours. Moreover, Selank was found to increase memory trace stability for up to 30 days. The researchers observed that the peptide's nootropic activity and ability to enhance memory storage processes was likely due to its significant impact on serotonin levels in the brain [3].

Reducing Stress and Anxiety

Researchers may consider the anxiolytic benefits of Selank as a reference for the potential effects of N-Acetyl Selank Amidate. Here are the latest data on Selank's anxiolytic potential:

• In a noninferiority study featuring 62 individuals diagnosed with generalized anxiety disorder (GAD), the anxiety-relieving impact of intranasal Selank was evaluated against medazepam, a medication known for its antidepressant and anti-anxiety properties. Selank was comparably effective to medazepam in alleviating GAD symptoms. Moreover, Selank mitigated the decline in tau (1/2) leu-enkephalin levels, correlating with the severity of GAD, and showed antiasthenic and psychostimulant qualities [11].
• A study in 60 adults with anxiety disorders reported that 14 days of intranasal Selank therapy led to mild nootropic and pronounced anxiolytic effects. The peptide was slightly less effective when compared to phenazepam but came with none of its negative effects such as drowsiness and dizziness. Quite the opposite, Selank also exhibited mild nootropic effects. Its anxiolytic effect persisted for a week after the 14-week course [2].

Neuroprotection

Preliminary evidence suggests that Selank may have neuroprotective effects, especially in stressed test animals. Researchers may consider the following data as a reference for N-Acetyl Selank Amidate's potential:

• In one study, Selank exerted nootropic effects on healthy rats and neuroprotective effects in outbred rats receiving 10% ethanol as the only fluid source for 30 weeks. Selank prevented the formation of memory and attention disturbances induced by chronic alcohol consumption and subsequent withdrawal. These effects were thought to be mediated by Selank's ability to modulate BDNF [15].
• Selank may also exert neuroprotective effects during stress by lowering pro-inflammatory cytokines. Test animals exposed to social stress experienced significantly increased pro-inflammatory cytokines IL-1β, IL-6, and TGF-β1. Selank led to a decrease in the concentration of these pro-inflammatory cytokines, effectively reaching control levels. The peptide also restored anti-inflammatory cytokine IL-4 levels, which tends to decrease under conditions of stress [16].

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Side Effects of N-Acetyl Selank Amidate

No research has specifically been undertaken on the safety and side effects of N-Acetyl Selank Amidate. Thus, researchers may consider referring to the available data on Selank safety.

Based on a Selank safety study, there are no side effects related to its use when administered for up to 21 days at a maximum dose of 2700mcg/daily. The peptide also was reported to offset the negative effects of other anxiolytics like benzodiazepines [14].

Researchers should consider potential side effects related to the route of administration. Minor side effects associated with nasal application of N-Acetyl Selank Amidate include:

• Nasal dryness
• Throat irritation
• Hypersensitivity
• Bacterial contamination

Some researchers may opt for injectable N-Acetyl Selank Amidate for their studies. Subcutaneous injections may infrequently result in:

• Pain
• Induration
• Bleeding
• Redness
• Swelling

Although some research suggests a potential for increased hair loss due to elevated BDNF levels, it remains uncertain whether Selank, which boosts BDNF expression, carries this risk [17].

As for long-term use, there is speculative concern about desensitization of the GABA receptors in the nervous system, leading to increased anxiety, depression, and insomnia. However, no empirical evidence supports this claim [18].

Given the limited safety data, some experts recommend cycling off Selank after 2-3 weeks of administration to test subjects. The peptide is also approved in Russia for consecutive daily use for up to 14 days, followed by a washout.

Based on these data, researchers may consider cycling N-Acetyl Selank Amidate on and off to avoid potential side effects. Further research is needed for a more comprehensive safety assessment.

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N-Acetyl Selank Amidate Dosage Calculator and Guide

Due to the aforementioned lack of research, there are no official N-Acetyl Selank Amidate dosing guidelines. Yet, intranasal Selank has been studied extensively, and its recommended dosage range may be used as a starting point for N-Acetyl Selank Amidate research.

Selank is officially prescribed in Russia for managing GAD in the form of 0.15% Selank nasal drops. Based on the medication’s package insert, it can be administered for up to 14 days at a dose of two drops (75mcg per drop) given thrice daily, for a total of 450mcg.

After completing the 14-day course, a break from one to three weeks is recommended before the treatment is repeated for another 14 days [19].

Clinical studies have also used Selank at doses of up to 900mcg administered three times daily for 21 days [14].

When referring to these data, researchers should consider that N-Acetyl Selank Amidate is available for research as a nasal spray rather than nasal drops. Further, most sprays contain 0.3% N-Acetyl Selank Amidate and deliver 300mcg per pump.

Therefore, experts advise initiating N-Acetyl Selank Amidate studies with 2-3 pumps/daily.

N-Acetyl Selank Amidate Cycle Length

There is a lack of data on the optimal N-Acetyl Selank Amidate cycle length. Researchers may thus consider adhering to the recommendations for Selank cycling, which suggest administering the peptide daily for 2-3 weeks, followed by a 1-3 week washout period [14, 19].

Cycling the peptide on/off is recommended to minimize the potential risk of GABA receptor desensitization following prolonged Selank use, even despite the lack of data suggesting a risk or occurrence of such desensitization.

Data on the risk of desensitization due to N-Acetyl Selank Amidate administration are also lacking. Still, researchers should lean on the side of safety and avoid dosing the peptide for more than 14 consecutive days.

Reference N-Acetyl Selank Amidate Dosing Protocol

Based on existing Selank data, here is a sample dosing protocol for N-Acetyl Selank Amidate:

• Daily Dosage: Start with 600-900mcg/daily of intranasal N-Acetyl Selank Amidate, administered via one pump (300mcg) 2-3 times/daily. Adjust the dose as needed but do not exceed 9 pumps a day.
• Frequency: Administer 2-3 times daily at consistent intervals.
• Study Duration: Continue for up to 14 days, followed by at least a one-week break. A subsequent two-week course may be initiated if required.
• Monitoring and Safety: Vigilantly monitor for adverse reactions via EEG and clinical status. Discontinue N-Acetyl Selank Amidate application immediately if negative effects occur.

Microdosing N-Acetyl Selank Amidate?

Nasal sprays containing N-Acetyl Selank Amidate deliver a minimum of 300mcg, which is considered a standard dose for this peptide. No scientific or anecdotal evidence suggests the viability of administering smaller doses intranasally, or microdosing.

Microdosing may be better suited for injectable peptides. Researchers who have chosen N-Acetyl Selank Amidate injections, note that the peptide should be first reconstituted and then administered subcutaneously following safety guidelines.

Due to the absence of established dosage and safety information for Selank and N-Acetyl Selank Amidate, we recommend a conservative dosing regimen of 150-300mcg/daily for up to two weeks. The potential of lower doses or microdosing N-Acetyl Selank Amidate remains unexplored.

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Where to Buy N-Acetyl Selank Amidate Online? | 2024 Edition

N-Acetyl Selank Amidate is readily available for purchase online by qualified researchers and laboratory professionals.

Given the growing number of vendors offering this peptide online, it is imperative for researchers to carefully assess their options before making a purchase.

At Peptides.org, we strongly recommend purchasing research peptides exclusively from vendors that source their products from accredited U.S. facilities and subject them to independent third-party testing for purity verification.

In our experience, Limitless Life Nootropics stands out as a highly reputable supplier of N-Acetyl Selank Amidate nasal spray. The vendor distinguishes itself through:

• Quality Assurance: Limitless is committed to the quality and purity of their peptides, verified through rigorous third-party laboratory testing. Each peptide comes with a comprehensive Certificate of Analysis for customer assurance.
• Customer Service Excellence: Limitless is dedicated to customer satisfaction and promptly addresses any shipping discrepancies.
• Flexible Payment Options: Limitless accommodates various payment methods, including Revolut, CashApp, Zelle, and cryptocurrencies, even offering discounts for cryptocurrency transactions.

Researchers interested in injectable N-Acetyl Selank Amidate should consider this supplier, another trusted vendor that adheres to the same stringent standards of peptide quality and customer care.

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N-Acetyl Selank Amidate Dosing Guide | Verdict

N-Acetyl Selank Amidate is a modified version of the potent research peptide Selank, approved in Russia for treating anxiety disorders. In addition, the peptide also appears to have potent nootropic and potential neuroprotective effects.

Considering that the modifications of N-Acetyl Selank Amidate are primarily aimed at improving the molecule's stability, experts state the modified version should have similar effects to standard Selank, which we’ve outlined in this guide.

Researchers interested in studying the effects of intranasal N-Acetyl Selank Amidate should head over to premier vendor Limitless Life Nootropics.

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