N-Acetyl Selank Amidate | Reviews, Clinical Studies, and Safety

While there is currently a lack of research into N-Acetyl Selank Amidate specifically, it is expected to have similar effects and potentially enhanced benefits compared to Selank peptide.

Accordingly, we will now outline the key benefits of Selank as observed in research studies.

N-Acetyl Selank Amidate for Stress and Anxiety Reduction

Selank has been clinically studied for its anxiolytic and anti-stress potential.

Most notably, one noninferiority trial in 62 patients with generalized anxiety disorder (GAD) sought to compare the anxiolytic action of intranasal Selank to that of medazepam, an antidepressant and anxiolytic drug. Here are the most notable findings reported by the study’s authors [12]:

• Selank appears to have similar efficacy in reducing symptoms of GAD as the established anxiolytic medazepam.
• GAD appeared to be associated with decreased tau (1/2) leu-enkephalin levels. The application of Selank offset the decrease.
• In addition to Selank’s potent anxiolytic effects, the peptide was also observed to have antiasthenic and psychostimulatory properties.

N-Acetyl Selank Amidate for Cognitive Enhancement

Clinical studies on Selank suggest that the peptide may have nootropic effects, namely in research subjects with anxiety-related disorders.

Some researchers have even suggested that the peptide may potentiate the benefits of common anxiolytic medications while reducing the risk of side effects. Here are the most notable study findings on the topic:

• A study in 70 anxiety disorder patients applied either oral phenazepam alone or in combination with intranasal Selank. The study authors reported that Selank significantly enhanced the anxiolytic medication’s effectiveness. The combination therapy also mitigated common side effects often associated with benzodiazepines, including memory loss, attention deficits, asthenia, and drowsiness [15].
• Another study in 60 anxiety disorder patients reported that Selank therapy led to mild nootropic effects and pronounced anxiolytic potential [6].
• Murine studies have also suggested that Selank may improve serotonin metabolism in the CNS while enhancing memory storage processes [7].

N-Acetyl Selank Amidate and Immunomodulation

Selank appears to also have immunomodulatory effects, particularly under stress conditions and in mood disorders such as depression and generalized anxiety disorder.

Here are two of the most noted studies on the topic:

• One study in stressed laboratory animals reported that Selank effectively reduced concentrations of pro-inflammatory cytokines like IL-1β, IL-6, and TGF-β1 while restoring levels of anti-inflammatory cytokine IL-4. This suggests that Selank has stress-protective activity and could modulate stress-related immune responses [16].
• A clinical study reported that 14 days of Selank administration suppressed the gene expression of IL-6 in the peripheral blood of patients with depression. Moreover, the peptide altered the Th1/Th2 cytokine balance in GAD patients to a more favorable ratio, indicating its potential as an immunomodulator in anxiety disorders [17].