CJC-1295 vs. Ipamorelin | A Comprehensive Comparison

Researchers investigating peptides with muscle growth potential may be interested in a comprehensive comparison of CJC-1295 vs. ipamorelin.

Both compounds work by stimulating the release of growth hormone (GH) from the pituitary gland, which is associated with benefits and effects like:

• Higher IGF-1 levels
• Increased lean mass
• Improved bone mass

In addition, some scientists may consider using a CJC-1295 and ipamorelin blend to potentially achieve even greater GH stimulation and beneficial effects.

After reading this article, researchers can better understand the similarities and differences between CJC-1295 and ipamorelin in terms of their mechanisms, research applications, and potential side effects.

We’ll also discuss where to source research-grade CJC-1295, ipamorelin, and CJC-1295/ipamorelin blends online.

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What is CJC-1295?

CJC-1295 is a research peptide composed of the initial 29 amino acids found at the N-terminus of the endogenous growth hormone-releasing hormone (GHRH) [1, 2].

These 29 amino acids form the shortest GHRH analog that triggers the release of GH from the anterior pituitary gland [1, 2]. Yet, the sequence also has a half-life of just 10 minutes when subcutaneously administered to healthy subjects [3].

CJC-1295 has several modifications for improved pharmacokinetics, including the substitution of four amino acids in the original 29 amino acid chain, which improves the peptide’s stability and effectiveness [4, 5, 6]:

• At the second position, L-alanine is replaced with D-alanine, heightening resistance to the enzyme dipeptidyl peptidase-4 (DPP-4), which plays a crucial role in deactivating many peptide-based medications.
• At the eighth position, asparagine is replaced with glutamine.
• At the fifteenth position, histidine is substituted with alanine.
• At the twenty-seventh position, cysteine is replaced with leucine.

CJC-1295 is often further modified with a drug affinity complex (DAC), made up of N-epsilon-3-maleimidopropionamide, that is attached to the peptide's C-terminus and extends CJC-1295's half-life to up to eight days [7].

CJC-1295 was first synthesized by Canadian firm ConjuChem Biotechnologies, which sought a targeted treatment for lipodystrophy in HIV/AIDS patients. Lipodystrophy manifests as abnormal fat distribution, marked by diminished fat in the face and limbs and increased abdominal and visceral fat, often as a side effect of antiretroviral medication.

CJC-1295 has reached phase 2 trials, but development was discontinued following a fatal myocardial infarction in a participant shortly after their 11th dose of CJC-1295 [8, 9].

Although the sponsor deemed that the death was unlikely directly related to the peptide, it took the decision to halt any future trials on HIV/AIDS patients. CJC-1295 has not received any approval for human use but is currently available for research and academic purposes.

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What is Ipamorelin?

Ipamorelin (NNC 26-0161) is a five-amino-acid research peptide that stimulates the release of GH by activating the ghrelin receptors (the growth hormone secretagogue receptors) in the pituitary gland.

Receptors for ghrelin are present in several systems and organs, including the brain, where they directly stimulate hunger and indirectly prevent low blood sugar by promoting the secretion of GH.

It is important for researchers to know the following about ipamorelin:

• Ipamorelin was developed and patented in 1994 by Novo Nordisk and Helsinn Therapeutics. It was designed to replicate the actions of ghrelin in the digestive system, specifically in improving peristalsis [10].
• Early studies indicated its potential in treating post-surgical ileus, a type of bowel paralysis that often occurs after gastrointestinal operations. Phase 2 clinical trials showed some positive outcomes, but these were not sufficiently significant over a treatment period of 7-10 days, leading to the halt of development [11, 12].
• Ipamorelin is highly selective compared to other GH secretagogues, as it stimulates GH production in the anterior pituitary gland without affecting the release of hormones such as prolactin and ACTH [13].
• Ipamorelin is capable of significantly increaing GH levels within 40 minutes following subcutaneous administration. The effects on GH could persist for 2-3 hours post-injection, although ipamorelin has a relatively brief half-life of under two hours [14].

Current investigations explore ipamorelin’s potential for supporting gastrointestinal health, enhancing bone density, and contributing to the development of lean muscle mass.

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CJC-1295 vs. Ipamorelin | Comprehensive Comparison

While CJC-1295 and ipamorelin are both capable of stimulating the synthesis of GH, the two peptides have significantly different mechanisms of action.

CJC-1295 appears to increase mean GH levels for extended periods of time, while ipamorelin may induce short-term supraphysiological spikes in GH synthesis.

Here are two notable studies that outline the GH-increasing effects of both CJC-1295 and ipamorelin:

• CJC-1295 administered as a subcutaneous injection to healthy study volunteers resulted in an increase in overall GH levels while maintaining GH pulsatility, with peak levels staying within normal ranges. Notably, a dose of 60mcg/kg resulted in an approximate 150% rise in mean GH levels, while a single dose of 250mcg/kg resulted in a 300% increase in 24-hour mean GH. When administered biweekly (twice over 14 days) at 60mcg/kg, this regimen consistently raised mean GH levels, with the effect persisting by day 28 [15].
• Comparatively, ipamorelin may induce significant GH pulses, particularly at higher doses. Research in healthy volunteers revealed that a single dose of ipamorelin at 100mcg/kg body weight significantly raised GH, with peaks reaching around 80mIU/l (approximately 26.6ng/ml). Elevated GH levels were also observed with smaller doses (60mcg/kg). Additionally, the same study indicated significant increases in GH even at a dosage of 10mcg/kg [14].

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Research Applications and Benefits of CJC-1295

The available clinical studies report that CJC-1295 also induces a significant increase in insulin-like growth factor 1 (IGF-1), which is the main anabolic mediator of GH.

Even a single CJC-1295 DAC injection has been reported to elevate IGF-1:

• Ionescu et al. (2006) reported a 44% increase in mean IGF-1 following a single CJC-1295 injection at the dose of 60-90mcg/kg [16].
• Teichman et al. (2006) also reported a 50%-200% increase in IGF-1 for about 10 days following a CJC-1295 injection at a dose between 30-250mcg/kg [15]

In addition, preclinical experiments involving longer administration periods report that the peptide can have significant benefits for growth and body composition.

Here are the most notable findings from a study involving mice with growth hormone deficiency—a condition that leads to stunted growth, reduced lean mass, and increased abdominal fat [17]:

• Enhanced growth and lean body mass: Growth hormone deficient (GHD) mice exhibited approximately 20% less lean body mass than normal, struggling to attain regular body size or weight. Daily administration of CJC-1295 resulted in the normalization of lean body mass.
• Reduction in body and visceral fat: Mice with GHD showed signs of visceral obesity, a condition that heightens the risk of metabolic diseases. CJC-1295 in these mice brought visceral fat levels back to normal.

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Research Applications and Benefits of Ipamorelin

Although long-term clinical studies with ipamorelin are lacking, there are numerous preclinical experiments suggesting that continuous administration can increase IGF-1 and result in related benefits.

For example, in a laboratory experiment in rats, ipamorelin led to a 54% increase in IGF-1 levels. This was linked to improved bone mineral density in the tested animals [18].

Moreover, ipamorelin could potentially contribute to gains in muscle and overall body weight due to its appetite-enhancing effects stemming from ghrelin receptor activation.

As a consequence, the peptide might lead to fat accumulation rather than reduction, as its substantial hunger-inducing impact could offset the fat-burning benefits of increased GH levels.

The increase in muscle and total body weight may also provide some benefits for increasing bone strength. Here are some notable findings from animal studies in this regard:

• Laboratory research suggests that ipamorelin may contribute to an increase in body mass, influenced by both lean and fat mass gains. A notable 16.9% increase in body mass was observed in test animals over a two-week period. This effect was attributed to the peptide's ability to elevate GH levels and stimulate appetite [19].
• Mouse models have demonstrated ipamorelin's effectiveness in reducing bone loss by promoting mineralization and preserving muscle strength, particularly in specimens exposed to corticosteroids. The peptide was found to counteract the muscle and bone-degenerative impacts of corticosteroids [20].

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CJC-1295 Side Effects and Complications

In clinical applications, CJC-1295 administration occassionally produces reactions at the injection site and a range of mild to moderate side effects, such as [15, 16]:

• Rapid heartbeat
• Headaches
• Abdominal discomfort
• Facial flushing
• Loose stools
• Nausea

It is crucial to acknowledge that this peptide has not been authorized for human use by the United States Food and Drug Administration or comparable regulatory body, and its safety profile has not been extensively studied in large-scale clinical trials.

The longest trial conducted to date was terminated following an incident of fatal myocardial infarction, which was determined to be unrelated to administration of CJC-1295 itself [8].

Test subjects with a history of cancer are typically excluded from studies involving GH secretagoguges due to concerns that elevated GH levels could affect the progression of cancer.

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Ipamorelin Side Effects and Complications

Clinical investigations into ipamorelin have generally found no side effects barring reactions at the injection site and minor gastrointestinal issues such as nausea.

However, ipamorelin studies to date have lasted not longer than one week and have primarily involved patients recovering from abdominal surgery [11].

On the other hand, preclinical experiments have found that the main side effects of ipamorelin are increased appetite and weight gain (including fat accumulation) [21].

GH secretagogues including ipamorelin are also contraindicated for subjects with cancerous conditions, due to their potential to elevate GH levels, accelerate cell growth, and impact disease progression.

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CJC-1295 and Ipamorelin | Synergistic Effects

There is strong research interest in the simultaneous application of GHRH analogs like CJC-1295 and ghrelin receptor agonists like ipamorelin.

Some studies have suggested that such combinations may result in synergistic effects, ultimately producing greater benefits compared to administering either peptide alone [22].

While there is strong interest in the potential of administering CJC-1295 and ipamorelin together, there is no published research to indicate whether these peptides have any synergistic or negative effects when combined.

Nevertheless, some researchers have proposed that CJC-1295 and ipamorelin may work synergistically and, therefore, may consider opting for blends of the two peptides for experimental purposes.

A mix containing both ipamorelin and CJC-1295 is specifically thought to stimulate a greater response from the pituitary cells by triggering GH release via different receptors.

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Where to Buy Research Peptides Online? | 2024 Edition

When sourcing peptides for research, it is crucial for researchers to work strictly with quality compounds that meet standards of purity.

The online marketplace is unfortunately replete with unreliable suppliers offering inferior products.

To combat this problem, our team of experienced researchers has conducted a thorough survey of the available online vendors of reference materials, identifying the following top supplier of CJC-1295, ipamorelin, and a CJC-1295/ipamorelin blend.

Limitless Life

Limitless Life stands out as the most reliable and cost-effective source of research-grade peptides online.

Here is why we consistently endorse this vendor:

• Strict Quality Assurance: Limitless Life implements comprehensive quality control measures to ensure that all of their products meet strict quality and purity standards.
• Smooth Transaction Process: The SSL-secured website offers a streamlined and safe checkout experience, with support for various payment options including credit cards and Cash App.
• Complimentary Shipping & Excellent Support: Limitless Life’s proactive support and service team is available by phone and email and responds to all queries within one business day. Domestic orders of $350+ are eligible for free shipping.

With their extensive catalog, commitment to product quality and safety, and fantastic customer support, Limitless Life sets industry standards of dependability and excellence.

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Ipamorelin and CJC-1295 | Verdict

Ipamorelin and CJC-1295 are two research peptides recognized for their effectiveness in elevating serum GH levels.

This effect facilitates increased IGF-1 production, with potential benefits like improved body composition, bone mass, and cellular growth.

Experts believe that combining these two peptides may lead to a synergistic effect that stems from their unique mechanisms of action.

CJC-1295 is a GHRH analog that stimulates the GHRH receptors, while ipamorelin activates the ghrelin receptors throughout the body, increasing GH levels but also stimulating appetite and peristalsis.

Researchers delving into the potential of CJC-1295 and ipamorelin are encouraged to visit our top recommended vendor of research peptides.

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