CJC-1295 | Reviews, Clinical Trials, and Safety

CJC-1295 may promote deep sleep: Several studies have suggested that GHRH plays a direct role in improving the quality of sleep. As CJC-1295 is a synthetic analogue of GHRH, there is strong research interest in the role it may play in sleep.

Fehm et al. investigated intranasal administration of GHRH and documented the effect it had on sleep quality. The study was performed according to a double-blind cross-over design and involved 12 young and 11 old healthy male test subjects, each of whom were intranasally administered 300 micrograms GHRH or placebo 30 min before bedtime [8].

Sleep was recorded polysomnographically until 7 am and blood was collected in 15 minute intervals for determination of cortisol and GH. Apart from the well-known age-related changes in hormonal secretion and sleep, intranasal GHRH had the following effects:

• Reduced cortisol nadir concentrations at the beginning of sleep (P < 0.05)
• Reduction in sleep-induced elevation in GH concentrations during early sleep
• Increased rapid-eye-movement (REM) sleep
• Increased slow-wave sleep (SWS), with this influence concentrating on the second half of sleep time

Based on these findings, intranasal GHRH appears to help regulate sleep processes and hypothalamic-hypophysiotropic secretory activity in both young and elderly male test subjects. This suggests that GHRH mimics the dual neuronal and endocrine function of hypothalamic GHRH activity.

Sleep helps recovery from muscle injury [9]. GH has been shown to enhance non-REM sleep after a period of sleep deprivation [10]. As a GHRH analogue, CJC-1295 is being actively investigated for its potential to produce deep, restorative sleep in subjects.

CJC-1295 may increase muscle mass: CJC-1295’s documented ability to increase levels of GH and IGF-1 has prompted research interest in the role that it may play in increasing muscle mass. CJC-1295 stimulates protein synthesis and supports muscle mass growth. While research in this area is ongoing, it remains to be determined whether healthy subjects may receive anabolic benefit from increased GH and IGF-1 [11].
Researchers interested in exploring CJC-1295’s purported effect on muscle mass may consider a blend of CJC-1295 and ipamorelin. This peptide combination has been linked to increased protein synthesis and muscle mass growth.

CJC-1295 may stimulate fat loss: Studies have shown that prolactin promotes visceral fat accrual in various animal models [12] and that CJC-1295 can normalize prolactin levels as shown in GHRH knockout mice [13], which can lead to increased fat metabolization. These findings have led to strong research interest in the role that CJC-1295 may play in fat loss through prolactin regulation.

Researchers interested in exploring CJC-1295’s purported ability to stimulate fat loss may consider a blend of CJC-1295 and GHRP-2. GHRP-2 also stimulates GH release from the anterior pituitary by acting on a different receptor to CJC-1295, called the growth hormone secretagogue receptor (GHSR). Studies in animal models have shown that GHRP-2 has a positive effect on muscle mass, heart function, and the immune system, suggesting that it may work synergistically when administered with CJC-1295.