Buy MK-677 | The A-Z Guide

Drawing on data from past trials, we summarize three key MK-677 benefits observed to date:

• Promotes lean body mass production: The main appeal of MK-677 from a research standpoint is that it is a growth hormone secretagogue (GHS) that raises levels of growth hormone and promotes lean body mass production [2]. Studies have shown that MK-677 can stimulate the secretion of endogenous GH in test subjects while avoiding risks associated with GH, such as increased all-cause mortality in GH deficient children [3] and increased risk of harm in GH deficient adults [4].
   
  One study examined the use of ibutamoren mesylate (MK-677) on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children [5]. The authors concluded that short-term administration of MK-677 can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency after only seven days of therapy.
   
  Two short-term clinical studies have found that MK-677 can positively impact body composition in test subjects:

• • A 1998 study by Murphy et al. found that MK-677 reversed diet-induced catabolism in a group of eight healthy young volunteers who were put on a diet of 14 days [6]. In this study, MK-677 was found to preserve nitrogen balance to a greater extent than placebo.
  • A two-month trial by Svensson et al. found that obese men who received MK-677 gained 3 kg more fat-free mass (FFM) compared with the placebo group [7].

These studies indicate that further research testing MK-677’s effects on lean body mass production may be warranted.

• Improves quality and duration of sleep: A 1997 study found that MK-677 has a strong effect on the quality and duration of sleep. The study found that test subjects who were treated with 25 mg MK-677 daily experienced a 50% increase in stage 4 sleep duration and an over 20% increase in REM sleep duration [8]. Given the ability of MK-677 to extend these critical sleep stages in healthy subjects, further investigation of the compound for its sleep-related benefits is warranted.

• Improves bone health: There is strong research interest in the effect of MK-677 on bone health. A 1999 study by Murphy et al., found that MK-677 improved bone turnover in elderly patients in just nine weeks [9]. When compared with placebo, MK-677 produced a 29.4% increase in mean serum osteocalcin, according to the study. The study concluded that MK-677 promoted bone turnover in the subjects based on positive indicators of bone resorption and formation.