CJC-1295 Benefits and Research Applications

Researchers curious about potential CJC-1295 benefits are in the right place.

This powerful research peptide has caught the attention of numerous researchers due to its purported physiological and neuroprotective benefits. But as a research chemical, it has yet to undergo or complete any clinical trials.

This has led to strong research interest in CJC-1295 benefits and potential applications.

This comprehensive review will aim to answer questions that peptide researchers may have about CJC-1295 benefits including its side effects, legal status, safety record, and more. 

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What is CJC-1295?

CJC-1295 is a peptide that’s a synthetic analogue of growth hormone-releasing hormone (GHRH). In other words, it’s a modified version of the first 29 amino acids in GHRH. It was developed by, and named after, ConjuChem Technologies, a Canadian Biotech company [1].

The version of CJC-1295 developed by ConjuChem is also known as CJC-1295 DAC, or DAC:GRF, which stands for drug affinity complex:growth hormone-releasing factor. This is the type of CJC-1295 that we’ll be referring to in this discussion of CJC-1295 benefits.

While the purported benefits of CJC-1295 have yet to be tested in human clinical trials, this peptide is believed to enhance athletic performance. CJC-1295 and body composition is now a hot research topic, and the peptide is currently being investigated as an alternative to growth hormone (GH) that offers comparable benefits with fewer side effects [2].

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Is CJC-1295 Legal?

Although both CJC-1295 DAC and CJC-1295 no DAC are widely used by researchers, these peptides are not FDA-approved and remain restricted to researchers. Where available for sale, CJC-1295 is sold strictly for in vitro testing and laboratory experimentation.

Athletes beware: Due to its performance-enhancing potential, CJC-1295 is prohibited by the World Anti-Doping Agency (WADA) as falling under Section S2 of its Prohibited List [3], and is banned from all major drug-tested competitive sports.

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What Are the Different Types of CJC-1295?

The CJC-1295 peptide was initially developed because GHRH has a very short half-life of around seven minutes. Created in the 1980s, CJC-1295 no DAC, also known as Mod GRF (1-29), had a half-life of up to 30 minutes. This was still far from ideal. But thankfully, alternatives to CJC-1295 no DAC have since been developed. We call attention to two in particular:

• CJC-1295 DAC
• CJC-1295 Ipamorelin

Let’s take a look at both of these CJC-1295 no DAC alternatives, and see how CJC-1295 DAC differs from CJC-1295 Ipamorelin.

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What is CJC-1295 DAC?

CJC-1295 DAC is a far improved version of CJC-1295 no DAC, and has a longer half-life of around six to eight days. DAC, which stands for Drug Affinity Complex, helps to protect the peptide after it’s injected, resulting in a much longer half-life. CJC-1295 DAC is a “bioconjugate,” meaning it’s a complex molecule that contains two smaller molecules, one of which is biologically active [4].

It’s believed that CJC-1295 DAC is more efficient than its predecessor and has a stronger effect on levels of cortisol and prolactin. However, these claims have not been verified through human studies.

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What is CJC-1295 + Ipamorelin?

CJC-1295 + Ipamorelin is a blend of growth hormone-releasing peptide (CJC-1295 no DAC) with growth hormone-releasing hormone (Ipamorelin). Ipamorelin is a “secretagogue,” meaning that it increases the specificity of CJC-1295. Data from animal studies suggests that it has a lesser effect on cortisol and prolactin levels than CPC-1295 DAC [5].

In these studies, researchers have mixed CJC-1295 (no DAC) and Ipamorelin in a 1:1 ratio with the Ipamorelin acting as a short-term trigger and CJC-1295 acting as a long-term trigger. As CJC-1295 Ipamorelin has a longer half-life than CJC-1295 DAC, it is believed to be more potent. However, this theory has not been tested in human clinical studies.

Now that we’ve outlined the two key iterations over the original CJC-1295, let’s look at the potential benefits offered by this peptide.

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Benefits of CJC-1295 | Top 5

Many theorized and purported benefits of CJC-1295 are based on animal studies [5] and have yet to be explored in human clinical trials. At the time of writing, with no clinical trials of CJC-1295 yet completed, most purported CJC-1295 benefits remain clinically untested. Further studies are necessary to explore how CJC-1295 behaves in the human body and with different cell groups.

But, what are the proven benefits of CJC-1295?

Longer Half-Life Than Growth Hormone

The main proven benefit of CJC-1295 is that it has a much longer half-life than GH and other GH analogues. CJC-1295 DAC has an estimated half-life of 5.8-8.1 days, according to the findings of a randomized, double-blind, placebo-controlled trial by Teichman et al in 2006 [6]. In a before-and-after comparison, test subjects had significantly elevated levels of GH up to eight days after receiving a subcutaneous injection.

Prolonged Stimulation of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1)

The second proven benefit of CJC-1295 is that it offers a prolonged stimulation of the release of both GH and Insulin-Like Growth Factor 1 (IGF-1). Researchers found that CJC-1295 DAC causes a 2-10 fold increase in plasma growth hormone concentration for six days and a 1.5-4 fold increase in plasma IGF-1 concentration for 9-12 days [6].

Potential Therapeutic Uses

As IGF-1 is used to treat growth hormone insensitivity syndrome (GHIS) [7], and CJC-1295 has been shown to increase both GH and IGF-1 [6], it has been theorized that CJC-1295 may offer therapeutic benefits associated with IGF-1 therapy [8]. To date, there is no empirical data to support these claims.

Potential Performance Enhancement

Although CJC-1295 hasn’t been tested in clinical trials, it is believed to be used in athletics by those seeking to improve athletic performance [9]. While there is convincing evidence that GH can help improve exercise capacity in people with a GH deficiency [10], there is no scientific evidence that GH therapy helps healthy individuals with normal GH levels.

The practice of administering GH or an analogue of GH to patients with a GH deficiency is known as “GH replacement.” It’s theorized to help increase oxygen delivery to muscles, leading to increased strength and improved body composition. However, there is no evidence that GH or CJC-1295 improves physical performance in healthy individuals [11].

Potential Neuroprotective Properties

Growth hormone (GH) has a significant influence on cognitive performance and this suggests that GH-boosting peptides like CJC-1295 may help improve spatial learning and memory. In one animal study, mice with altered growth hormone action “showed significantly better learning parameters” than those without [12]. This has led to speculation that GH analogues like CJC-1295 may help with neuropathological and neurodegenerative conditions or offer neuroprotective properties.

Scientific data supporting CJC-1295’s effectiveness is sparse given that it’s a research chemical not intended for human consumption. Next, we’ll dive into this peptide’s side effects.

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CJC-1295 Side Effects

According to the 2006 double-blind, placebo-controlled study by Teichman et al, subcutaneous injections of CJC-1295 DAC caused “no serious adverse reactions” in test subjects [6]. The study actually compiled the findings of two separate trials. The study actually compiled the findings of two separate trials. The first trial involved administering a single dose of CJC-1295 DAC to test subjects, while the second trial involved administering two or three doses of CJC-1295 DAC per week.

The authors of the study noted that subcutaneous administration of CJC-1295 DAC was “relatively well tolerated” when doses were higher than 30 μg/kg and lower than 60 μg/kg. They also found that CJC-1295 DAC had “cumulative effect after multiple doses.” [6].

With smaller doses (up to 30 μg/kg) of CJC-1295 DAC, some of the mild adverse effects experienced by the test subjects included:

• Mild injection site reactions,
• Irritation,
• Erythema,
• Induration,
• Pain, and
• Itching.

With higher doses of CJC-1295 DAC (over 30 μg/kg), the most common side effects were:

• Headaches,
• Diarrhea,
• Flushing, and
• Mild hypotension.

Although these side effects occurred in approximately 70 percent of test subjects receiving CJC-1295 DAC, they were transient and lasted no more than a few hours.

Now that we’ve reviewed the safety of the CJC-1295 peptide, let’s look at where to buy some online.

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Where to Buy CJC-1295 Online? | 2024 Edition

Researchers looking to buy CJC-1295 are encouraged to visit our preferred vendors, known for their commitments to peptide quality and customer care.

Below, we break them down by DAC, no DAC, and CJC-1295 + Ipamorelin blend:

CJC-1295 No DAC

For researchers looking to source CJC-1295 No DAC, we can safely recommend:

Limitless Life

At Peptides.org, we understand the quality of research peptides can make or break a research project. That’s why we recommend working with Limitless Life as a research peptide supplier. 

We like them because of their outstanding commitment to third party testing for each of their products, their reputation, and their responsive customer service team.

Here’s a bit more about why we recommend Limitless Life:

• Outstanding Quality Commitment: Limitless Life works with three different independent laboratories, which conduct tests on each batch of product to ensure quality.
• Reputable and Trustworthy: With high customer ratings and a low rate of credit card charge-backs, Limitless Life has earned a stellar reputation within the larger research peptide community.
• Responsive Support and Service: It’s extremely easy to reach Limitless Life’s service team, because they are available 7 days per week via phone or email.
• Accredited and Recognized for Business Practices: Because Limitless Life is accredited by the Better Business Bureau, researchers can trust that they have excellent business practices.

Also…

Using our exclusive discount code, researchers can get 10% off their next order at Limitless Life. Just use the button below and add the code:

peptidesorg10

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CJC-1295 DAC

For researchers looking to source CJC-1295, we recommend this top-rated peptides source:

Research Chemical

They are considered one of the top peptides vendors in the world. Here's why

• Third-Party Testing: Research Chemical has all their CJC-1295 batches purity tested with third-party labs. This ensures the highest quality peptides. Then the company posts results of the testing on their website for reference.
• Multiple Payment Options: Research Chemical offers reliable credit card payments with all major brands. They also offer cryptocurrency payments for researchers.
• Quick, Simple Shipping: Research Chemical offers same-day and next-day fulfillment standard. This allows researchers to get peptides in an efficient manner, thus beginning their studies with speed.

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CJC-1295 No DAC + Ipamorelin

For researchers looking for a blend formulation, CJC-1295 No DAC + Ipamorelin, we again recommend this top-rated vendor:

Limitless Life

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Bacteriostatic Water and CJC-1295

To correctly administer CJC-1295, researchers will need access to certain supplies, such as bacteriostatic water and sterile vials. This is true whether sourcing CJC-1295 DAC or CJC-1295 No Dac.

Searching the internet for all of these supplies may be frustrating and time-consuming for researchers. However, it is required for research.

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CJC-1295 Benefits | Verdict

Researchers curious about CJC-1295 benefits have hopefully had their questions addressed and answered in this guide. While human research involving this peptide is sparse and little is known about its benefits, peptide research on animal studies indicates that it may hold potential for further research and human trials. 

Researchers interested in working with CJC-1295 will note that we have highlighted a number of directions that future research could take, most notably its safety compared with GH therapy and its potential effectiveness in the research space.

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